منابع مشابه
Regulation of cytoplasmic dynein ATPase by Lis1.
Mutations in Lis1 cause classical lissencephaly, a developmental brain abnormality characterized by defects in neuronal positioning. Over the last decade, a clear link has been forged between Lis1 and the microtubule motor cytoplasmic dynein. Substantial evidence indicates that Lis1 functions in a highly conserved pathway with dynein to regulate neuronal migration and other motile events. Yeast...
متن کاملNeurobiology of Disease Regulation of Cytoplasmic Dynein ATPase by Lis1
Mariano T. Mesngon,1 Cataldo Tarricone,3 Sachin Hebbar,1 Aimee M. Guillotte,1 E. William Schmitt,2 Lorene Lanier,4 Andrea Musacchio,3 Stephen J. King,2 and Deanna S. Smith1 1Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, 2Division of Molecular Biology and Biochemistry, University of Missouri–Kansas City, Kansas City, Missouri 64110, 3Department ...
متن کاملCytoplasmic dynein.
The organization and function of eukaryotic cells rely on the action of many different molecular motor proteins. Cytoplasmic dynein drives the movement of a wide range of cargoes towards the minus ends of microtubules, and these events are needed, not just at the single-cell level, but are vital for correct development. In the present paper, I review recent progress on understanding dynein's me...
متن کاملCytoplasmic dynein nomenclature
A variety of names has been used in the literature for the subunits of cytoplasmic dynein complexes. Thus, there is a strong need for a more definitive consensus statement on nomenclature. This is especially important for mammalian cytoplasmic dyneins, many subunits of which are encoded by multiple genes. We propose names for the mammalian cytoplasmic dynein subunit genes and proteins that refl...
متن کاملRegulation of cytoplasmic dynein function in vivo by the Drosophila Glued complex
The Drosophila Glued gene product shares sequence homology with the p150 component of vertebrate dynactin. Dynactin is a multiprotein complex that stimulates cytoplasmic dynein-mediated vesicle motility in vitro. In this report, we present biochemical, cytological, and genetic evidence that demonstrates a functional similarity between the Drosophila Glued complex and vertebrate dynactin. We sho...
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ژورنال
عنوان ژورنال: Microscopy and Microanalysis
سال: 2015
ISSN: 1431-9276,1435-8115
DOI: 10.1017/s1431927615001099